Southwest Chicken Alfredo

When I first started cooking for myself, there was nothing more satisfying than finding a recipe that felt both indulgent and achievable. One night, after a long day, I stumbled upon the idea of blending rich Alfredo with bold Southwest flavors. That simple twist transformed a basic meal into something truly special—hearty, vibrant, and so comforting. This Southwest Chicken Alfredo quickly became my go-to when I needed something quick and guaranteed to impress.

If you’re just starting out in the kitchen, this recipe is perfect for you. It’s straightforward, fast enough for a busy weeknight, and loaded with wholesome ingredients. Plus, it’s a fantastic way to explore how spices and creaminess can work together in perfect harmony, making it an excellent choice for anyone looking for quick and healthy meals that don’t sacrifice flavor.

Southwest Chicken Alfredo

Why This Recipe is Special

Southwest Chicken Alfredo stands out because it fuses two beloved cuisines into one seamless dish. Imagine tender chicken strips seasoned with smoky spices, tossed in a creamy, cheesy sauce, and wrapped around hearty pasta. It’s comforting yet exciting, rich without being overwhelming. Better still, you can customize it easily to fit what you have in your pantry. Whether you’re cooking for yourself, family, or guests, this lemon herb chicken recipe alternative will win hearts—and taste buds—every time.

Ingredients and Preparation

Chicken Breasts bring protein and tenderness to the dish. They soak up the Southwest seasoning beautifully, ensuring each bite is packed with flavor.
Penne Pasta acts as the perfect vessel to hold all the creamy sauce. Other short pastas like rotini or farfalle work just as well if you prefer.
Diced Tomatoes provide a subtle acidity that cuts through the richness, keeping the sauce balanced and fresh.
Heavy Cream is the magic behind the luscious, velvety texture of the sauce. For a lighter option, you can substitute half-and-half.
Cheddar Cheese offers bold flavor and creamy meltiness. Sharp cheddar, mild cheddar, or a Mexican cheese blend are all excellent choices.
Onion delivers sweetness and depth when sautéed, building the foundation of the sauce’s flavor. Yellow, white, or even sweet onions are all suitable.
Garlic Cloves add aromatic richness—fresh cloves make a noticeable difference, but garlic powder can be a handy substitute in a pinch.
Honey gives a hint of sweetness that balances the savory spices, making the chicken irresistibly delicious.
Cilantro offers a bright, fresh finish to the creamy pasta. If you’re not a fan, parsley is a good alternative.
Olive Oil and Butter are used to cook the chicken and vegetables, enhancing both flavor and texture.
Southwest Seasoning Blend (Chili Powder, Cumin, Oregano, Paprika, Black Pepper, Salt, and Cayenne) gives the dish its bold, zesty character. Feel free to adjust the cayenne if you prefer less heat.

Step-by-Step Instructions

Step 1 Start by mixing together all the spices to create your Southwest seasoning blend. This ensures the flavors are evenly distributed when seasoning the chicken.

Step 2 Cut your chicken breasts into strips and place them in a large bowl. Drizzle with honey and sprinkle half of the seasoning mix over the top, tossing to coat thoroughly.

Step 3 Bring a large pot of salted water to a boil. Add the penne pasta and cook according to the package directions until al dente. Drain and set aside, reserving a little pasta water just in case you need to thin the sauce later.

Step 4 Heat olive oil in a large skillet over medium heat. Once the oil is shimmering, add the seasoned chicken strips. Cook them for a few minutes on each side until golden brown and fully cooked (internal temperature should reach 165°F).

Step 5 Remove the chicken from the skillet and set aside. In the same pan, melt butter and sauté chopped onion over medium heat until translucent, about 3–4 minutes. Add the minced garlic and cook for an additional minute until fragrant.

Step 6 Stir in the diced tomatoes and the remaining seasoning blend. Let the mixture simmer gently to deepen the flavors.

Step 7 Gradually pour in the heavy cream while stirring continuously. Once the sauce is smooth and simmering, return the cooked chicken to the skillet.

Step 8 Sprinkle the shredded cheddar cheese into the sauce and stir until fully melted and combined.

Step 9 Add the cooked pasta to the skillet and toss everything together, ensuring the pasta is well coated with the creamy sauce. Let it sit off the heat for a few minutes to thicken slightly.

Step 10 Just before serving, sprinkle fresh chopped cilantro over the pasta for a burst of color and brightness. Give it one final toss and enjoy your easy sheet pan dinner masterpiece.

Beginner Tips and Notes

  • If your chicken starts browning too quickly, lower the heat slightly and add a splash of water to prevent burning.
  • If your sauce feels too thick, stir in a bit of the reserved pasta water, one tablespoon at a time, until it loosens to your desired consistency.
  • Prep all your ingredients before you start cooking (a technique called “mise en place”) to make the cooking process smoother and less stressful.
  • No large skillet? You can cook the chicken in batches in a medium skillet to avoid overcrowding, then combine everything in a large pot.

Serving Suggestions

This Southwest Chicken Alfredo pairs beautifully with simple sides like a crisp green salad or homemade garlic bread. For something extra hearty, serve it alongside roasted vegetables such as asparagus, bell peppers, or zucchini.

Leftovers can be stored in an airtight container in the refrigerator for up to three days. To reheat, simply warm gently on the stove over low heat or microwave in short bursts, adding a splash of cream or milk to refresh the sauce if needed.

Conclusion

I hope you feel excited and confident to tackle this Southwest Chicken Alfredo in your own kitchen. It’s a quick and healthy meal that’s packed with flavor, perfect for beginner cooks looking to impress with minimal stress. When you try it, I’d love to hear how it turns out for you—feel free to drop a comment and share your experience!

FAQ About Southwest Chicken Alfredo

1. Can I use a different type of pasta instead of penne?

Yes, you can substitute penne with any short-cut pasta like rotini, farfalle, or even rigatoni. Just be sure to cook it al dente so it holds up well with the sauce.

2. How can I make this dish a little healthier?

To lighten it up, you can use half-and-half instead of heavy cream and swap in a reduced-fat cheese. You can also add extra vegetables like spinach or bell peppers.

3. What if I don’t have fresh cilantro?

If fresh cilantro isn’t available or you’re not a fan, chopped fresh parsley makes a great substitute. You can also skip it altogether if preferred.

4. How spicy is Southwest Chicken Alfredo?

The dish has a mild to medium spice level. If you are sensitive to heat, you can simply reduce or omit the cayenne pepper in the seasoning blend.

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Southwest Chicken Alfredo

Southwest Chicken Alfredo


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  • Author: Ashely
  • Total Time: 30 minutes
  • Yield: 4 servings 1x
  • Diet: Halal

Description

A creamy, bold, and beginner-friendly Southwest Chicken Alfredo featuring tender chicken, smoky spices, and a rich cheese sauce tossed with pasta.


Ingredients

Scale
  • 1 lb Chicken Breasts, cut into strips
  • 1/2 lb Penne Pasta
  • 1 (15 oz) can Diced Tomatoes
  • 1 cup Heavy Cream
  • 1 1/2 cups Cheddar Cheese, shredded
  • 1 cup Onion, chopped
  • 4 Garlic Cloves, minced
  • 1 tablespoon Honey
  • 1 tablespoon Olive Oil
  • 1 tablespoon Butter
  • 2 tablespoons Fresh Cilantro, chopped
  • 1 1/2 teaspoons Chili Powder
  • 1/2 teaspoon Cumin
  • 1/2 teaspoon Oregano
  • 1 teaspoon Paprika
  • 1/4 teaspoon Black Pepper
  • 1/2 teaspoon Salt
  • 1/8 teaspoon Cayenne Pepper

Instructions

  1. Mix the Southwest seasoning blend together in a small bowl.
  2. Cut chicken into strips, drizzle with honey, and toss with half of the seasoning blend.
  3. Bring a large pot of salted water to a boil and cook penne pasta until al dente; drain and set aside.
  4. Heat olive oil in a large skillet over medium heat, cook chicken until golden and cooked through, then transfer to a plate.
  5. In the same skillet, melt butter and sauté onions until tender, then add garlic and cook for one more minute.
  6. Add diced tomatoes and remaining seasoning, simmering gently to blend flavors.
  7. Slowly pour in heavy cream while stirring; bring to a simmer, then return chicken to the skillet.
  8. Sprinkle in cheddar cheese and stir until melted and smooth.
  9. Add cooked pasta and toss to fully coat in sauce; let sit for a few minutes off heat.
  10. Sprinkle chopped cilantro over the pasta just before serving and enjoy.

Notes

  • If the sauce becomes too thick, loosen it with a splash of reserved pasta water.
  • Reduce or omit cayenne pepper if a milder spice level is preferred.
  • Fresh parsley can be substituted for cilantro.
  • Store leftovers in an airtight container in the fridge for up to 3 days.
  • Reheat gently with a little cream or milk to refresh the sauce.
  • Prep Time: 5 minutes
  • Cook Time: 25 minutes
  • Category: Main Course
  • Method: Stovetop
  • Cuisine: American

Nutrition

  • Serving Size: 1 plate
  • Calories: 1092
  • Sugar: 49g
  • Sodium: 921mg
  • Fat: 48g
  • Saturated Fat: 25g
  • Unsaturated Fat: 17g
  • Trans Fat: 0.1g
  • Carbohydrates: 121g
  • Fiber: 20g
  • Protein: 57g
  • Cholesterol: 190mg

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